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Just bored with work Colon fuck in that want Girls to life at the moment. We aimed to assess and explain sex differences in 5-year relative survival using standard and model-based period analysis amongpatients diagnosed with CRC from to and reported to 11 German cancer registries covering a population of 33 million inhabitants.

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Age-adjusted 5-year relative survival was higher in women A substantial survival advantage of women was confirmed in multivariate analysis after adjusting for CRC stage and subsite in subjects under 65 years of age relative excess risk, RER 0. On the contrary, sex differences in survival did not vary by location of CRC. In conclusion, our large population-based study confirmed a survival advantage of female compared to male CRC patients, most notably in young and middle aged patients and patients with localized disease.

The effect of sex hormones, either endogenous or through hormonal replacement Colon fuck in that want Girls to, might Colon fuck in that want Girls to the most plausible explanation for the observed patterns. January 14, ; Accepted: May 26, ; Published: July 5, Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Competing interests: The authors have declared that no competing interests exist. Introduction Colorectal cancer CRC is Colon fuck in that want Girls to third most common cancer and the fourth most common cancer cause of death, accounting for more thandeaths per year globally [1]. In most countries, incidence and mortality rates are considerably higher in men than in women [2]. On the other hand, Colon fuck in that want Girls to regarding sex differences in prognosis have been less consistent.

Several studies reported superior survival in females [3][4][5] ; however, other studies did not report any difference [6]. Two recent studies examined potential variation of sex differences in survival of CRC patients by age. Whereas younger women exhibited better survival than younger men, an opposite pattern was seen among older patients [7][8].

As the age cut off around 50 years was chosen as a surrogate for natural menopause, it was hypothesized that the survival advantage of female patients at younger age could be partially explained by favourable effect of endogenous female sex hormones. Other factors potentially accounting for sex differences in survival are differences in use of screening offers and stage at diagnosis, and differences in site distribution of CRC. Offer and use of screening examinations vary between countries [9].

Sincecolonoscopy has been offered as primary screening examination from age 55 on. Participation rates have been higher in women than in men for both FOBT and screening colonoscopy, especially in younger age groups, which may have contributed to a higher proportion of early stages and better prognosis [10][11].

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As a different mediator of survival advantage in women, higher postoperative morbidity in men leading to early deaths unrelated to CRC was hypothesized [12]. On the other hand, CRC is more often located in the proximal colon among women Colon fuck in that want Girls to ; this was reported to be a rather unfavourable prognostic Colon fuck in that want Girls to [14][15].

We aimed to compare survival from CRC between men and women and to explore potential reasons for sex differences in a large population-based cancer survival study from Germany. Materials and Methods Sources of Data As this was a retrospective epidemiological study based on anonymised cancer registry data, neither approval of the ethics committee nor patient Castillos Webcam xxx in consent was needed.

This analysis is part of a collaborative project aiming for comprehensive monitoring of cancer survival in Germany. Full details were described elsewhere [16].

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